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Extracellular NAD + can enter cells via pore-forming channel connexin 43 (Cx43), a bi-directional NAD + transporter allowing exogenous NAD + transportation into the cell, and transportation out for utilization of NAD + by CD38 64

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Arch Toxicol 2017;91:761–73 [DOI] [PMC free article] [PubMed] [Google Scholar] 87.Lee KK, Imaizumi N, Chamberland SR, Alder NN, Boelsterli UA.Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury